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KMID : 0921620210510010037
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Journal of Bacteriology and Virology
2021 Volume.51 No. 1 p.37 ~ p.38
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Uptake of Host Metabolic Succinate Correlates with Salmonella Virulence Induction
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Choi Yoon-Seok
Koh Young-Sang
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Abstract
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Accumulation of succinate promotes Salmonella pathogenic program during intracellular infection. Using RNA-seq, increased mRNA expression of the genes in pmrAB and Salmonella pathogenicity island2 (SPI-2) regulon is measured in succinate-containing medium. Furthermore, uptake of host metabolic succinate through DcuB transporter also induces program for Salmonella virulence. Thus, succinate is major factor of Salmonella enterica serovar Typhimurium (S.Tm)
virulence induction.
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KEYWORD
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Succinate, Salmonella enterica serovar Typhimurium, dcuB, Salmonella pathogenicity island 2 (SPI-2), PhoPQ, PmrAB, Intracellular infection
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